DNA damage and apoptosis in mussel Mytilus galloprovincialis (CROSBI ID 91862)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Mičić, Milena ; Bihari, Nevenka ; Jakšić, Željko ; Mueller, Werner E.G. ; Batel, Renato
engleski
DNA damage and apoptosis in mussel Mytilus galloprovincialis
The effects of known model substances (4-nitroquinoline-N-oxide, benzo(a)pyrene, teniposide, etoposide, cycloheximide, tributyltin) on human cells (FLC, HL-60) and on mussels were investigated. The correlations between formation of DNA strand breaks and DNA fragmentation characteristic for process of apoptosis were estimated. Strand breaks induced by 4-nitroquinoline-N-oxide and benzo(a)pyrene did not correlate with DNA fragmentation detected in the process of apoptosis. Induction of internucleosomal DNA fragmentation in HL-60 cells was found to be initiated by teniposide, etoposide and tributyltin, while in gills of mussel this was detected only with tributyltin. Neither high molecular weight DNA nor internucleosomal DNA fragmentation fragmentation was observed in haemocytes of mussels. Levels of DNA strand breaks in natural mussel populations, living at locations under the influence of urban and industrial wastes, do not mirror the apoptotic processes.
DNA strand breaks; benzo(a)pyrene; 4-nitroquinoline-N-oxide; tributyltin; mussel; apoptosis; alkaline elution
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