engleski

Serum lipid levels in female patients with affective disorders

Lipids are the important constituent of the neuronal cell membrane. The role of the serum lipids (total cholesterol, high-density lipoprotein cholesterol /HDL-C/, low-density lipoprotein cholesterol /LDL-C/, triglycerides /TG/) in the pathophysiology of the mood disorders is not clear. The aim of this study was to determine serum lipids profiles in patients with major depression, bipolar depression and healthy control. MATERIAL AND METHODS. The study included medication free female subjects: 41 patients with bipolar disoder (22 in manic and 19 in depressive phase), 34 patients with major depression and 37 healthy controls. Patients were classified according to DSM-IV criteria. Serum lipids levels were determined using standard laboratory tests. RESULTS. Patients with major depression and bipolar disorder in both phases had lower HDL-C levels than healthy controls. Increased TG levels were found in patients with bipolar disorder as compared to healthy subjects. The changes in lipids profiles persisted when data were adjusted for age and smoking. There were no changes in the other lipids levels. The significant differences were found in the ratios of the cholesterol/HDL-C and LDL-C/HDL-C (atherogenic index) among groups. A negative correlation between cholesterol levels and YMRS total score was observed in manic patients. CONCLUSION. The results suggest that low HDL-C levels and the ratios of the cholesterol/HDL-C and LDL-C/HDL-C could be the hallmarks of the affective disorders. Since low HDL-C levels could be a risk factor for the development of coronary heart disease, further investigation of the lipids metabolism in affective disorders is warranted.

total cholesterol; high-density lipoprotein cholesterol; low-density lipoprotein cholesterol; triglycerides; mood disorders

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