engleski

Interleukin-6 mRNA expression in sporadic colon cancer

Colon cancer is one of the most frequently diagnosed cancers in Western Societies. Interleukin-6 (IL-6) is a potent, pleiotropic, inflammatory cytokine that contributes to a multitude of physiological and pathophysiological processes. IL-6 is produced by many different cell types. The main sources in vivo are stimulated monocytes, fibroblasts, and endothelial cells. A variety of studies have demonstrated that over expression of IL-6 contributes to the pathogenesis of various inflammatory diseases as well as cancer. It has been reported that human colorectal cancer cells display a wide heterogeneity in their potential to express and produce IL-6. Serum levels of IL-6 are elevated in patients with colorectal cancer, however serum levels of IL-6 were found to be independent of IL-6 mRNA expression in tumor tissue. In this study we analyzed IL-6 mRNA expression by real-time PCR in 50 sporadic colon cancer tissue as well as corresponding normal mucous tissue. IL-6 mRNA expression in tumor tissue was lower than in the corresponding normal mucous tissue (p=0, 0074). There was no correlation between IL-6 mRNA expression and tumor grade or stage. Thus we can conclude that IL-6 produced at the tumor site is not involved in sporadic colon cancer progression.

IL-6; sporadic colon cancer

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