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Regulatory IL16 -295 SNP polymorphism and cerebral palsy

Introduction: Cerebral palsy (CP) is a nonprogressive motor disorder caused by white matter damage in the developing brain. It is often accompanied with neurocognitive and sensory disabilities. The cause and pathogenesis of CP is multifactorial and continues to be poorly understood. Chorioamnionitis, clinically silent or manifest, has been reported to be a risk factor for CP both in term and preterm infants. IL-16 gene is single copy gene located on chromosome 15q26.1-3 in humans. Interleukin-16 is synthesized by a variety of immune (T cells, eosinophils and dendritic cells) and non-immune (fibroblasts, epithelial and neuronal) cells. It is also detected in organ-specific secretions in a number of inflammatory processes. Amniotic fluid interleukin-16 concentrations decreased with advancing gestational age. But, women with preterm labor and women with chorioamnionitis have higher interleukin 16 amniotic fluid concentrations than those who delivered at term or those with sterile amniotic fluid. The aim of our study was to estimate allelic frequency for regulatory IL16 -295 SNP in the children with the CP. Methods: DNAs obtained from peripheral blood of 46 CP patients and 182 unrelated healthy volunteers were genotyped for the IL16 -295 SNP PCR-RFLP method. Results and Conclusion: IL16 -259 genotype  CC was more common in the population with cerebral palsy in the comparison to healthy volunteers. The significance of the association between IL16  gene polymorphisms and cerebral palsy has to be investigated in the future studies.

IL16; SNP; cerebral palsy

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