engleski

Evolution of Alpha Satellite DNA

Alpha satellite DNA is based on 171-bp tandem repeats located in the centromeric regions of all primate chromosomes. It evolves through a series of amplification events resulting in the spreading of “ new” subfamilies which replace the “ old” ones and confer centromere function. Alpha satellite transcripts play an important role in kinetochore formation and the establishment of pericentromeric heterochromatin.

alpha satellite DNA ; higher order repeats ; centromere ; heterochromatin ; concerted evolution

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