The role of the Amadori product in the complications of diabetes (CROSBI ID 35817)
Prilog u knjizi | izvorni znanstveni rad
Podaci o odgovornosti
Monnier, V.M ; Sell, D.R. ; Dai, Z. ; Nemet, Ina ; Collard, F. ; Zhang, J.
engleski
The role of the Amadori product in the complications of diabetes
Strong evidence has emerged in recent years in support of an association between advanced glycation and the complications of diabetes, whereby both glycoxidation products and oxoaldehydes have been implicated. In contrast, except for the fact that skin collagen-linked fructosamine (Amadori product) is a strong predictor of the risk of progression of microvascular disease in humans, Amadori products have not been associated with complications in most animal experiments. Below we develop the hypothesis that glucose-derived advanced glycation end products (AGEs), such as glucosepane, may inflict sustained damage to the extracellular matrix in diabetes and contribute to tissue stiffening and accelerated sclerosis in arteries, kidneys, and other organs as supported by immunochemical studies using a glucosepane antibody. We also hypothesize that many more structures derived from Amadori products with nucleophiles, such as primary amines and thiols, are expected. The selective prevention of Amadori-derived AGEs using deglycating enzymes would be desirable. However, x-ray diffraction studies of Amadoriase I crystals show that the active site of the enzyme is deeply embedded, explaining why this approach is unlikely to succeed in vivo. Preliminary experiments with nucleophiles show that aminoguanidine and other compounds block glucosepane in vitro.
Amadori, glycation, diabetes, AGE, glucosepane
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nije evidentirano
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Podaci o prilogu
81-88.
objavljeno
Podaci o knjizi
Schleicher, E. ; Somoza, V. ; Schieberle, P.
New York (NY): Wiley-Blackwell
2008.
1-57331-719-5