engleski

Formation of enantiopure 5-substituted oxazolidinones through enzyme-catalysed resolution of epoxides

Halohydrin dehalogenase from Agrobacterium radiobacter catalyzed the enantioselective ring opening of terminal epoxides with cyanate as a nucleophile, yielding 5-substituted oxazolidinones in high yields and with high enantiopurity (69-98% ee). This is the first example of the biocatalytic conversion of a range of epoxides to the corresponding oxazolidinones.

Cyanate; Epoxides; Oxazolidinones; Halohydrin dehalogenase; Kinetic resolution

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