engleski

Tandem repetitive DNA sequences in (peri)centromeric regions

Genomic composition, copy number and/or nucleotide sequence of satellite DNAs is usually a taxon-specific feature. The library model explains the occurrence of these differences by amplification-contraction of satellite families preexisting in a set common for a group of organisms. Despite rapid alterations in copy numbers, nucleotide sequences of some studied satellite DNAs can remain unchanged during extremely long evolutionary periods. Dual character of satellite DNAs, ability for long-time sequence conservation, and at the same time proneness to change their genomic composition can be a general feature of tandem repeats, what might be advantageous in some genomic regions such as in and around centromeres. A model of satellite DNA life cycle will be presented.

satellite DNA; heterochromatin; pericentromere; library model

Istraživačka radionica koju financira European Science Foundation pod naslovom Heterochromatin structure and function: from repetitive DNA sequences to epigenetics je projekt kojega je prijavio Miroslav Plohl u skupini LESC te je ocijenjen 6/16 mjestom.