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Codon usage in marine sponge Suberites domuncula

Sponges are the simplest extant phylum of Metazoa ; they are closest to the common ancestor of all multicellular animals. A total of 223 coding sequences from Suberites domuncula (Demospongiae) represent the dataset for the codon usage analysis. A total of 46037 codons had an average G + C content of 45.6% and average GC3S (G + C content at silent codon position) was 43.39%. In this sample of genes considerable variations in synonymous codon usage were found. The G + C content of coding sequences varied from 34 to 56.1% and GC3S from 19 to 58.7%. Correspondence analysis revealed that highly expressed genes preferentially use a limited subset of codons (preferred codons). A total of 15 preferred codons were found and they all (with one exception) end with C or G. We propose that the preference for C- and G-ending codons was already developed in a common ancestor of sponges and other Metazoa and it remained conserved throughout sponge evolution.

codon usage; sponges; Porifera; Suberites domuncula

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