Effects of α-Melanocortin Enantiomers on Acetaminophen-Induced Hepatotoxicity in CBA Mice (CROSBI ID 157733)
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Podaci o odgovornosti
Turčić, Petra ; Bradamante, Mirna ; Houra, Karlo ; Štambuk, Nikola ; Kelava, Tomislav ; Konjevoda, Paško ; Kazazić, Saša ; Vikić-Topić, Dražen ; Pokrić, Biserka
engleski
Effects of α-Melanocortin Enantiomers on Acetaminophen-Induced Hepatotoxicity in CBA Mice
Proteins and peptides in mammals are based exclusively on L-amino acids. Recent investigations show that D-amino acids exhibit physiological effects in vivo, despite of their very small quantities. We have investigated the hepatoprotective effects of the L and D-enantiomers of α-melanocortin peptide (α-MSH). The results showed that peptide enantiomerism is related to the protective effects of melanocortin peptides in vivo. L-α-MSH exhibited potent hepatoprotective effect in the experimental model of acetaminophen induced hepatotoxicity in male CBA mice, while its D-mirror image was inefficient. Furthermore, the antibody to the L-peptide did not recognize the D-structure. The results indicate that the opposite peptide configuration may be used to modulate its function and metabolism in vivo and in vitro.
enantiomer ; α-MSH ; hepatoprotection ; hepatotoxicity ; antibody ; CD spectroscopy
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