engleski

Synthesis of new steroid-beta-lactam hybrids via palladium-catalyzed aminocarbonylation

Steroid-beta-lactam and steroid-beta-lactam-ferrocene conjugates were synthesized via palladium-catalyzed carbonylation of steroidal 17-iodo-16-enes in the presence of 3-amino-azetidin-2-ones. beta-Lactam derivatives have been used for the first time as nucleophyles in the aminocarbonylation reaction. The products were obtained in good yields and were characterized by 1H- and 13C-NMR, IR and HRMS.

beta-lactams ; hybrids ; aminocarbonylation ; palladium ; alkenyl iodides

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