Fibrinolytic and anticoagulative activities from the earthworm Eisenia foetida (CROSBI ID 81270)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Hrženjak, Terezija ; Popović, Maja ; Božić, Tamara ; Grdiša, Mira ; Kobrehel, Đorđe ; Tiška-Rudman, Ljerka
engleski
Fibrinolytic and anticoagulative activities from the earthworm Eisenia foetida
Biologically active glycolipoprotein complex (G-90) isolated from whole earthworm tissue extract shows anticoagulative and fibrinolytic activities. We isolated two tyrosine like serine peptidases with molecular masses of 34 kDa (P I) and 23 kDa (P II), respectively. P I peptidase is autocatalytically degraded to P II. Both peptidases exhibit fibrinolytic and anticoagulative activities. The activity of P I is much higher. P I in concentration of 105 ng/ml of plasma shortened the physiological time of fibrin clot lysis by 54% and completely inhibited blood clotting at a concentration of 103 ng/ml of venous blood.
Eisena foetida; serine proteases
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
119 (4)
1998.
825-832-x
objavljeno
1096-4959