engleski

Monoisoamyl ester of DMSA reduces 203Hg(NO3)2 retention in rats: 2. Chelation therapy during lactation

Two chelating agents meso-2,3-dimercaptosuccinic acid (DMSA) and monoisoamyl ester of DMSA (Mi-ADMS) were compared in their efficiency to reduce inorganic mercury retention in dams and pups during lactation. Mercury-203 and chelating agents DMSA, or Mi-ADMS, in two doses of 0.5 mmol/kg each, were administered intraperitoneally to lactating dams as early treatment (0.5 and 24 h after Hg-203). Whole body retentions of Hg-203 in dams and pups were measured daily during the 7-day experiment. Results showed that whole body retention of mercury in dams decreased at a higher rate in the two experimental groups than in controls. At all intervals, values of the Mi-ADMS treated group were lower than those in the DMSA group. In pups, the whole body retention of mercury increased during the first 2 days in all groups. Third day onward, the retention levels in pups of treated dams were lower than in control. From the 4th through 7th days, pups from dams treated with Mi-ADMS had significantly lower mercury retention than pups from dams treated with DMSA. At the end of the experiment, retention of Hg-203 in the whole body and tissues (gut, liver, kidney, brain, and pelt) of DMSA or Mi-ADMS treated dams was reduced to 26-67% and 3-23% of control values, respectively. In suckling pups, whole body Hg-203 retention values (after DMSA or Mi-ADMS treatment of their darns) were reduced to 51% and 32% of control values, respectively. These effects in pups were due to lower Hg-203 retention in dams resulting from chelation treatment and not because of the transfer of chelating agents through breast milk to pups.

heavy metals; DMSA; Mi-ADMS; mercury retention; chelation treatment; mother rats; pups

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