engleski

Effect of Root Canal Sealers on Mouse Peritoneal Macrophage Functions

Three root canal filling materials: calcium hydroxide-based cement (Apexit®), resin-based cement (AH-plus®) and glass-ionomer based material (Ketac Endo®) were tested for their influence on several functions of peritoneal macrophages from Balb/c mice. Macrophage functions were evaluated by the adherence, phagocytic, candidacidal and Nitro blue tetrazolium (NBT)-dye assays. Ketac-Endo® enhanced all macrophage functions at the first 48 hours (p ≤ 0.05), when compared to the positive control, but this effect had changed after seven and 14 days, causing inhibition of these functions. Other materials suppressed substrate adherence capacity and phagocytosis, while significantly stimulated macrophage microbicidal activity (p ≤ 0.05) in a time-dependent manner.

root canal sealers; macrophage functions

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