Tumor Necrosis Factor-Alpha in Peripical Tissue Exudates of Teeth with Apical Periodontitis (CROSBI ID 137164)
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Pezelj-Ribarić, Sonja ; Magašić, Karolina ; Prpić, Jelena ; Miletić, Ivana ; Karlović, Zoran
engleski
Tumor Necrosis Factor-Alpha in Peripical Tissue Exudates of Teeth with Apical Periodontitis
Aim. The aim of this study was to determine tumor necrosis factor-alpha (TNF-α ) levels in periapical exudates and to evaluate their relationship with radiological findings. Methodology. Periapical exudates were collected from root canals of 60 single-rooted teeth using absorbent paper points. TNF-α levels were determined by enzyme-linked immunosorbent assays. The samples were divided into three groups according to the periapical radiolucent area. Results. Nonparametric Kruskal-Wallis test revealed significant differences between TNF-α concentrations in control group (40, 57± ; ; ; ; ; ; 28, 15 pg/mL) and group with larger radiolucent areas (2365, 79± ; ; ; ; ; ; 582, 95 pg/mL), as well as between control and canals with small radiolucent areas (507, 66± ; ; ; ; ; ; 278, 97) (P<.05). Conclusions. The levels of TNF-α increase significantly in teeth with periapical pathosis, from smaller to bigger lesions. This research and its results have shown that objective analysis of the TNF-α levels enables establishment of a relationship between different concentrations of TNF-α and different radiological changes.
tumor necrosis factor-alpha; periapical exudates
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