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Rapid voltammetric identification and determination of simvastatin at trace levels in pharmaceuticals and biological fluid (CROSBI ID 138788)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Nigović, Biljana ; Komorsky-Lovrić, Šebojka ; Devčić, Dubravka Rapid voltammetric identification and determination of simvastatin at trace levels in pharmaceuticals and biological fluid // Croatica chemica acta, 81 (2008), 3; 453-459

Podaci o odgovornosti

Nigović, Biljana ; Komorsky-Lovrić, Šebojka ; Devčić, Dubravka

engleski

Rapid voltammetric identification and determination of simvastatin at trace levels in pharmaceuticals and biological fluid

Simvastatin is used as an antilipemic agent through inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. The reduction behavior of drug has been studied in different supporting electrolytes within the pH range 3-9. Based on the adsorptive character of simvastatin onto the mercury electrode surface, a new cathodic square-wave stripping voltammetry method for its direct determination at trace levels has been proposed. The voltammetric response could be used to determine drug concentration in the range 1.0 × 10-8 - 7.5 × 10-7 mol L-1, with detection limit of 4.5 × 10-9 mol L-1. Applicability to biological fluid analysis was illustrated. The method was successfully employed, without sample pretreatment, for quantitation of the active ingredient simvastatin in pharmaceuticals. The use of abrasive stripping voltammetry for rapid identification of this drug in pharmaceutical dosage forms using a paraffin-impregnated graphite electrode has been examined.

simvastatin; square-wave voltammetry; abrasive stripping voltammetry; pharmaceuticals; biological fluid

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Podaci o izdanju

81 (3)

2008.

453-459

objavljeno

0011-1643

Povezanost rada

Kemija, Farmacija

Indeksiranost