engleski

Cyclodextrin-based pharmaceuticals

Cyclodextrins, cyclic oligosacharides, are useful pharmaceutical excipients, which have attracted widespread attention. The ground for their popularity from a pharmaceutical point of view is in their ability to change undesirable characteristics of the drugs, such as unpleasant taste, low aqueous solubility, chemical instability and improving the drug bioavailability by inclusion complex formation. Due to their biocompatibility, cyclodextrins may be used in formulations indented for different routes of drug application including oral, ocular, nasal and even parenteral route. This article outlines the importance and functionality of cyclodextrin in different dosage forms and indicates the possible directions of future development.

cyclodextrin; inclusion complex; drug delivery; aqueous solubility; chemical stability; bioavailability

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