A cis-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horse (CROSBI ID 145302)
Prilog u časopisu | Pismo (znanstveno) | međunarodna recenzija
Podaci o odgovornosti
Pielberg, Gerli Rosengren ; Golovko, Anna ; Sundström, Elisabeth ; Čurik, Ino ; Lennartsson, Johan ; Seltenhammer, Monika H. ; Druml, Thomas ; Binns, Matthew ; Fitzsimmons, Carolyn ; Lindgren, Gabriella ; Sandberg, Kaj ; Baumung, Roswitha ; Vetterlein, Monika ; ; Strömberg, Sara ; Grabherr, Manfred ; Wade, Claire ; Lindblad-Toh, Kerstin ; Pontén, Fredrik ; Heldin, Carl-Henrik ; Sölkner, Johann ; Andersson, Leif
engleski
A cis-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horse
Gray horses are born colored but gradually lose hair pigmentation and become white, a trait that is transmitted in an autosomal dominant manner. Leif Andersson and colleagues report that the the mutation causing the Gray phenotype is a 4.6-kb duplication in intron 6 of STX17, which promotes overexpression of both STX17 and the neighboring gene NR4A3 in melanomas from Gray horses.
stimulating-hormone-receptor; stem-cell maintenance; coat color gene; equus-caballus; mc1r; mechanisms; linkage; genome
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nije evidentirano
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nije evidentirano
Podaci o izdanju
Povezanost rada
Veterinarska medicina, Poljoprivreda (agronomija), Biologija
