engleski

Salivary and serum neuropeptides in patients with burning mouth syndrome

Burning mouth syndrome (BMS) is characterized by symptoms of burning in the oral cavity being diagnosed when not any other known causes of burning could be identified. It has been hypothesized that neuropathy might be causative to the BMS, being still matter of debate whether is it centrally or peripherally induced condition and which might be reflected in tachykinin levels. Therefore, the aim of this study was to evaluate salivary and serum substance P (SP), neurokinin A (NKA) and calcitonin-gene-related-peptide (CGRP) in 26 female patients with burning mouth syndrome (age range 51-78, mean 65.69 yrs), and 22 female controls (age range 24-82, mean 49.72 yrs). Serum and salivary SP, NKA, CGRP levels were determined by commercial competitive enzyme immunoassay kits and proteins were determined according to Bradford. Statistical analysis was performed by use of descriptive statistics and analysis of variance p values lower than 0.05 were considered as significant. Significantly decreased serum neurokinin A level in patients with burning mouth syndrome was found in comparison to the controls (p< 0.05). We might speculate that decreased serum neurokinin A levels might reflect inefficient dopaminergic system.

burning mouth syndrome; neurokinin A; substance P; CGRP

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