Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

CAST-ELISA Test in the Diagnosis of Allergy to Aditives (CROSBI ID 545304)

Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija

Turčić, Petra ; Rudolf, Maja ; Milavec-Puretić, Višnja ; Malenica, Branko CAST-ELISA Test in the Diagnosis of Allergy to Aditives // Canadian journal of clinical pharmacology / Canadian Society for Pharmacology and Therapeutics (ur.). 2008. str. e709-e709

Podaci o odgovornosti

Turčić, Petra ; Rudolf, Maja ; Milavec-Puretić, Višnja ; Malenica, Branko

engleski

CAST-ELISA Test in the Diagnosis of Allergy to Aditives

Allergy to additives can be in combination with food and drug allergy serious diagnostic and therapeutic problem. The mechanisms by which food additives affect the immune mechanisms are poorly understood. These reactions are described as intolerance or pseudoallergy and are not IgE-mediated. Concomitant drug allergy to vehicles must be diagnosed too. At present, detection of food additives allergy is still difficult and requires an adequate clinical examination and specific in vivo and in vitro diagnostic tests. The aim of the study was to investigate the diagnostic value of cellular antigen stimulation test (CAST) in detection of hypersensitivity reaction to additives. We tested 47 patients with positive history of hypersensitivity reactions to food additives (sodium salicylate, sodium benzoate, potassium metabisulfite and tartrazine). Clinical symptoms included urticaria/angioedema (25 patients), medicamentous exanthema (6 patients) and eczematous dermatitis (16 patients). Sulfidoleukotrienes (sLT) quantification was carried out by CAST-ELISA after in vitro peripheral blood leukocytes stimulation with food additives. The results higher than the cut-off range value (sodium salicylate 120 pg/mL, sodium benzoate. 90 pg/mL, potassium metabisulfite 40 pg/mL and tartrazine 120 pg/ml) were considered positive. Our results demonstrate that CAST was positive in 8% (4/45) of patients with allergy to sodium salicylate, 26% (12/45) of patients to sodium benzoate, 28% (13/37) of patients to potassium metabisulfite and 28 % (13/45) of patients to tartrazine. Our results show that increased sulfidoleukotriene production was observed with different frequency by any off the food additive tested. In vitro measurement of sLT production may be helpful or identifying some patients with allergy to food additive and drug allergy.

allergy; aditives; CAST-ELISA

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o prilogu

e709-e709.

2008.

nije evidentirano

objavljeno

Podaci o matičnoj publikaciji

Canadian journal of clinical pharmacology

Canadian Society for Pharmacology and Therapeutics

Quebec:

1198-581X

Podaci o skupu

World Conference on Clinical Pharmacology and Therapeutics (9 ; 2008)

poster

27.07.2008-01.08.2008

Quebec, Kanada

Povezanost rada

Farmacija

Poveznice
Indeksiranost