engleski

Influence of lecithin/chitosan nanoparticles on melatonin permeability

Indole amide neurohormone melatonin, secreted by the pineal gland, plays an important role in the body’ s internal time-keeping system. It regulates sleep-wake cycle and other circadian and seasonal rhythms. It is also known for its antioxidant and cytoprotective activity (1). Exogenous melatonin has been used in the treatment of various circadian rhythm disorders, like jet-lag and insomnia. Due to low oral bioavailability and poor water solubility, new routes of administration and delivery systems, are being investigated. In this study, lecithin/chitosan nanoparticles were evaluated in terms of size, surface charge, melatonin entrapment, and their influence on melatonin mucosal permeability. Lecithin/chitosan nanoparticles as melatonin delivery system have been successfully developed. Due to their positive surface charge originated from chitosan, they are suitable for mucosal delivery. Melatonin incorporation into lecithin/chito&not ; san nanoparticles did not impair its permeability.

Melatoni; Chitosan; Lecithin; Nanoparticles; Permeability

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