Structure and dynamics of hyaluronic acid semidilute solutions: a dielectric spectroscopy study (CROSBI ID 160917)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Vuletić, Tomislav ; Dolanski Babić, Sanja ; Ivek, Tomislav ; Grgičin, Danijel ; Tomić, Silvia ; Podgornik, Rudi
engleski
Structure and dynamics of hyaluronic acid semidilute solutions: a dielectric spectroscopy study
Dielectric spectroscopy is used to investigate fundamental length scales describing the structure of hyaluronic acid sodium salt (Na-HA) semidilute aqueous solutions. In salt-free regime, the length scale of the relaxation mode detected in MHz range scales with HA concentration as c_HA^{; ; -0.5}; ; and corresponds to the de Gennes-Pfeuty-Dobrynin correlation length of polyelectrolytes in semidilute solution. The same scaling was observed for the case of long, genomic DNA. Conversely, the length scale of the mode detected in kHz range also varies with HA concentration as c_HA^{; ; -0.5}; ; which differs from the case of DNA (c_DNA^{; ; -0.25}; ; ). The observed behavior suggests that the relaxation in the kHz range reveals the de Gennes-Dobrynin renormalized Debye screening length, and not the average size of the chain, as the pertinent length scale. Similarly, with increasing added salt the electrostatic contribution to the HA persistence length is observed to scale as the Debye length, contrary to scaling pertinent to the Odijk-Skolnick-Fixman electrostatic persistence length observed in the case of DNA. We argue that the observed features of the kHz range relaxation are due to much weaker electrostatic interactions that lead to the absence of Manning condensation as well as a rather high flexibility of HA as compared to DNA.
hyaluronic acid; dielectric spectroscopy; characteristic length scales
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
82
2010.
011922-1-011922-10
objavljeno
1539-3755
10.1103/PhysRevE.82.011922