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Antimicrobial activity of Thymus longicaulis C. Presl essential oil against respiratory tract pathogens (CROSBI ID 565537)

Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija

Vladimir-Knežević, Sanda ; Kosalec, Ivan ; Petrović, Marinko ; Ralić, Jovica ; Matica, Biserka Antimicrobial activity of Thymus longicaulis C. Presl essential oil against respiratory tract pathogens // Planta medica / Melzig, Matthias F. ; Kolodziej, Herbert (ur.). 2010. str. 1320-1320

Podaci o odgovornosti

Vladimir-Knežević, Sanda ; Kosalec, Ivan ; Petrović, Marinko ; Ralić, Jovica ; Matica, Biserka

engleski

Antimicrobial activity of Thymus longicaulis C. Presl essential oil against respiratory tract pathogens

Thymus longicaulis C. Presl is a small aromatic perennial herb of Lamiaceae family and a typical representative of the Illyric-Mediterranean flora. This species is a traditional remedy for cold, flu, cough, nephritis and abdominal pain [1]. Present study aimed to evaluate composition of essential oil and its in vitro antimicrobial activity against major respiratory tract pathogens which show increasing resistance to commonly prescribed antimicrobials [2]. The yield of essential oil obtained by hydrodistillation from aerial plant parts was 12 ml/kg. According to the GC-MS analysis, a total of 41 compounds (99%) were identified. Thymol (46.3%), γ-terpinene (16.2%), thymyl methyl ether (11.4%), and p-cymene (9.4%) were the main components. Antimicrobial activity of the essential oil was determined using microdilution broth assay (tested concentrations were 0.2-25 mg/ml). Amoxicillin-clavulanate and fluconazole were used in order to control sensitivity of tested clinically isolated bacterial and yeast strains: Haemophilus influenzae, Neisseria meningitidis, Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes and Candida albicans. The essential oil exhibited antimicrobial activity against all tested pathogens. The most sensitive strains were H. influenzae and S. pneumoniae (MIC 0.78 mg/ml), while S. aureus was the most resistant (MIC > 25 mg/ml). Our results revealed that T. longicaullis from Croatia is rich in essential oil characterized by a high content of thymol. A strong antimicrobial effect of the essential oil proved in this study indicates on its huge potential in the treatment of respiratory tract infections. References: 1. Kütür, S. (2007) J. Ethnopharmacol. 111:341–364. 2. Klugman, K.P. (2007) Int. J. Antimicrob. Agents 29:6-10.

Thymus longicaulis C. Presl; essential oil; GC-MS; antimicrobial activity

DOI: 10.1055/s-0030-1264801

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Podaci o prilogu

1320-1320.

2010.

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objavljeno

Podaci o matičnoj publikaciji

Planta medica

Melzig, Matthias F. ; Kolodziej, Herbert

Stuttgart: Georg Thieme Verlag

0032-0943

Podaci o skupu

International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (58 : 2010)

poster

29.08.2010-02.09.2010

Berlin, Njemačka

Povezanost rada

Farmacija

Indeksiranost