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Urates in Exhaled Breath Condensate of Children with Asthma

To find out whether urates as a marker of oxidative stress could be determined in exhaled breath condensate (EBC), and are there any differences in urate concentrations between asthmatic and healthy children. EBC was collected using an EcoScreen condenser. Urate measurements were performed by enzymatic color test. Asthmatic children were divided into two groups: children with controlled asthma and children with acute exacerbation of asthma. EBC urate concentration was statistically significantly higher in children with controlled asthma as compared with control group and acute exacerbation group. Seven children with acute exacerbation of asthma had unmeasurable urate concentrations. Study results showed EBC to contain measurable urate concentration, which was significantly higher in children with controlled asthma as compared with clinically healthy children and children acute exacerbation of asthma.

asthma; child; exhaled breath condensate; oxidative stress; urate

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