engleski

Allergen Specific Immunoglobulin E in Children Under 6 Years Old With Total Immunoglobulin E Below 10 kU/L

This study assesses the rate of sIgE antibody positive findings in children under six years of age with tIgE concentrations below 10 kU/L as well as the relationship between sIgE concentration and other diagnostic parameters. In vitro and in vivo findings were retrospectively analyzed in 193 children. There were significant differences in serum tIgE concentrations and peripheral blood eosinophil granulocyte counts between the groups of children with positive and negative sIgE findings. Negative skin prick test was found in 54% of children with positive sIgE findings. We suggest that sIgE concentrations be determined in children under six years of age irrespective of tIgE concentrations if allergy is indicated by clinical symptoms. Blood sampling for IgE determination should preferably be performed during the period of allergen exposure. Timely detection of sensitization is crucial to identify children at an increased risk of allergic disease.

allergy; children; hypersensitivity; immunoglobulin E; screening

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