engleski

Nucleation kinetics of cis-entacapone

The solubility curve and the metastable zone width for the system cis-entacapone - 2-propanol have been determined at the defined process conditions. These results along with values of induction period for the constant feed concentration at different levels of supersaturation were used for evaluating interfacial energy according to classical nucleation theory. Obtained results were used for calculation of the critical nucleus size, nucleation rate and prediction of crystal growth mechanism. Solubility data and metastable zone width determines the way of achieving the essential supersaturation level, as well as providing information necessary for control of crystallization process. Knowledge of the fundamental parameters of nucleation kinetics led to better understanding of crystallization process in order to obtain product with desired solid state characteristics.

crystal growth ; entacapone ; induction period ; metastable zone width ; nucleation ; solubility

nije evidentirano