engleski

Development of low methoxy amidated pectin-based mucoadhesive patches for buccal delivery of triclosan : Effect of cyclodextrin complexation

A novel mucoadhesive buccal patch formulation of triclosan (TR), a broad spectrum antibacterial agent, was developed using low methoxy amidated pectin (AMP). The integrity of AMP matrix was improved by addition of 20% (w/w) Carbopol (CAR). The efficiency of beta-cyclodextrin- epichlorohydrin polymer (EPIbetaCD) and anionic carboxymethylated beta-cyclodextrin- epichlorohydrin polymer (CMEPIbetaCD) in optimization of TR solubility and release from such a matrix was investigated and confronted to that of parent beta-cyclodextrin (betaCD). Loading of TR/betaCD co-ground complex into AMP/CAR matrix resulted in a biphasic release profile which was sensitive upon the hydration degree of the matrix, due to lower solubilizing efficiency of betaCD, while the drug release from patches loaded with TR/EPIbetaCD complex was significantly faster with a constant release rate. Microbiological studies evidenced faster onset and more pronounced antibacterial action of TR/EPIbetaCD loaded patches, clearly demonstrating their good therapeutic potential in eradication of Streptococcus mutans, a cariogenic bacteria, from the oral cavity.

triclosan; beta-cyclodextrin; water soluble polymeric beta

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