Utjecaj genskih polimorfizama na nastanak aneurizme trbušne aorte u ljudi (CROSBI ID 589776)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija
Podaci o odgovornosti
Dabelić, Sanja ; Crkvenac Gregorek Andrea ; Crkvenac Gornik Kristina ; Stupin Polančec Darija
engleski
Utjecaj genskih polimorfizama na nastanak aneurizme trbušne aorte u ljudi
Abdominal aortic aneurysm (AAA) is a complex genetic disorder, caused by unfavorable interplay of different genetic and environmental risk factors. DNA was isolated from blood samples of 234 Croatian individuals (117 with AAA and 117 healty controls). The allelic and genotype frequency of five polymorphism were determined: the number of (GT)n dinucleotide repeats in the heme oxygenase-1 gene promoter (HO-1), the deletion of 32 bp in the chemokine receptor 5 gene (CCR5), insertion/deletion of 287 bp in the angiotensin-converting enzyme (ACE) gene as well as two single nucleotide polymorphisms - in the angiotensin II type 1 receptor gene (SNP 1166A>C AT1R) and in the matrix metalloproteinase-9 gene (SNP -1562C>T MMP-9). Carriers of ACE DD genotype and MMP-9 -1562 TT genotype showed increased risk for developing AAA. Decreased risk for the developing showed carriers of HO-1 LL genotype, while other two polymorphisms were not associated with AAA. For the first time, Croatian subjects were genotyped for (GT)n HO-1 and SNP-1562C>T MMP-9.
aneurizma abdominalne aorte ; polimorfizmi
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o prilogu
126-127.
2012.
objavljeno
Podaci o matičnoj publikaciji
11th Croatian Biological Congress with International Participation - Proceedings of Abstracts
Jelaska, Sven ; Klobučar, Goran ; Šerić Jelaska, Lucija ; Leljak Levanić, Dunja ; Lukša, Žaklin
Zagreb: Hrvatsko biološko društvo
1848-5553
Podaci o skupu
11th Croatian Biological Congress with International Participation
pozvano predavanje
16.09.2012-21.09.2012
Šibenik, Hrvatska