Biochemomechanics of Intraluminal Thrombus in Abdominal Aortic Aneurysms (CROSBI ID 188822)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Wilson, John S. ; Virag, Lana ; DiAchille, Paolo ; Karšaj, Igor ; Humphrey, Jay D.
engleski
Biochemomechanics of Intraluminal Thrombus in Abdominal Aortic Aneurysms
Most computational models of abdominal aortic aneurysms address either the hemodynamics within the lesion or the mechanics of the wall. More recently, however, some models have appropriately begun to account for the evolving mechanics of the wall in response to the changing hemodynamic loads. Collectively, this large body of work has provided tremendous insight into this life-threatening condition and has provided important guidance for current research. Nevertheless, there has yet to be a comprehensive model that addresses the mechanobiology, biochemistry, and biomechanics of thrombus-laden abdominal aortic aneurysms. That is, there is a pressing need to include effects of the hemodynamics on both the development of the nearly ubiquitous intraluminal thrombus and the evolving mechanics of the wall, which depends in part on biochemical effects of the adjacent thrombus. Indeed, there is increasing evidence that intraluminal thrombus in abdominal aortic aneurysms is biologically active and should not be treated as homogenous inert material. In this paper, we bring together diverse findings from the literature to encourage next generation models that account for the biochemomechanics of growth and remodeling in patient-specific, thrombus-laden abdominal aortic aneurysms.
aorta; hemodynamics; stress analysis; biomechanics; inflammation; proteases; growth and remodeling
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Podaci o izdanju
135 (2)
2013.
021011-1-021011-14
objavljeno
0148-0731
10.1115/1.4023437