Neodredivi rezultati interferona gama ex vivo u imuno-nesuprimirane djece (CROSBI ID 599063)
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Podaci o odgovornosti
Pavić, Ivan ; Zrinski Topić, Renata
engleski
Neodredivi rezultati interferona gama ex vivo u imuno-nesuprimirane djece
Immunosuppressed individuals due to pathologic conditions (eg. HIV infection, hematologic malignancies, chronic renal failure) or therapeutic procedures (eg. organ transplantation, chemotherapy, immunosuppressive therapy with tumor necrosis factor α (TNF-α), therapy with systemic corticosteroids) are at high risk for reactivation of latent tuberculosis infection (LTBI), and require timely identification. Laboratory diagnosis of LTBI is based on the blood test determining interferon-gamma (IFN-γ) released from effector T-lymphocytes (interferon-gamma release assay, IGRA) upon stimulation with M. tuberculosis specific peptides. Two children with indeterminate results of IGRA are presented. They were free from congenital or acquired immunodeficiency disorders, as shown by their history data, clinical examination and laboratory findings. Case 1: a 15-month-old male infant was referred for testing because of cough and febrile condition persisting for a week before admission. Status: febrile, eupneic, pale, tachycardia, serous nasal discharge, pharyngeal congestion, normal breath sounds over lungs on auscultation. Examination and test findings indicated the diagnosis of pneumonia. Case 2: a 5.5-year-old female child was referred for testing due to persistent cough and subfebrile condition with serous nasal discharge for three days before admission. She was positive for contact with tuberculosis patient, as her uncle has been treated for microbiologically positive lung tuberculosis 3 years before. Examination and test findings indicated the diagnosis of lung tuberculosis. As no indeterminate results were found on repeat IGRA, it was assumed that acute bacterial inflammation (acute pneumonia or tuberculosis), could produce the indeterminate results recorded on initial testing. In acute inflammationa IGRA should be delayed.
interferon gamma; IGRA-test; non-immunosuppressed child
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Podaci o prilogu
A20-A20.
2012.
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objavljeno
Podaci o matičnoj publikaciji
Biochemia medica
Zagreb: Medicinska naklada
1330-0962
Podaci o skupu
23rd Symposium Croatian Society for Medical Biochemistry and Laboratory Medicine. Tuberculous infection – continuous challenge
predavanje
22.09.2012-22.09.2012
Zagreb, Hrvatska
Povezanost rada
Kliničke medicinske znanosti, Farmacija