engleski

Hematological, biochemical and toxicological investigations in spontaneous cases of mycotoxic nephropathy (ochratoxicosis) in pigs

Hematological, biochemical and toxicological investigations of blood and urine of normally slaughtered pigs exhibiting changes as enlarged mottled or pale kidneys in high percentage in the examined big batches at the slaughtering meat inspeciton were carried out with the aim of elucidating the nature of the nephropathies in pigs obseved in some regions in Bulgaria. The renal demages were characterized by impairment of proximal tubular function, manifested by an increased urinary excretion of glucose and protein, and by increased urea and creatinine concentration in blood, whereas the levels of serum protein and glucose were decreased. Specific gravity of the urine was decreased, but the value of pH was increased. The serum levels of potassium, sodim, aspartate-aminotransferase (ASAT) and glutamate dehydrogenase (GLDH) were increased. Toxicological investigations of serum samples from pigs exhibitin mottled appearance of kidneys revealed a content of ochratoxin A. The average concentration of all investigated serum samples (4.8 ng/ml) and percentage of contaminated samples (64 %) showed that ochratoxin A probably is a major etiological agent provoking the nephropathy.

ochratoxin A; mycotoxic nephropathy; ochratoxicosis

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