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izvor podataka: crosbi

Determination of parameters for successful spray coating of silicon microneedle arrays (CROSBI ID 195208)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

McGrath, Marie G. ; Vrdoljak, Anto ; O’Mahony, Conor ; Oliveira, Jorge C. ; Moore, Anne C. ; Crean, Abina M. Determination of parameters for successful spray coating of silicon microneedle arrays // International journal of pharmaceutics, 415 (2011), 1/2; 140-149. doi: 10.1016/j.ijpharm.2011.05.064

Podaci o odgovornosti

McGrath, Marie G. ; Vrdoljak, Anto ; O’Mahony, Conor ; Oliveira, Jorge C. ; Moore, Anne C. ; Crean, Abina M.

engleski

Determination of parameters for successful spray coating of silicon microneedle arrays

Coated microneedle patches have demonstrated potential for effective, minimally invasive, drug and vaccine delivery. To facilitate cost-effective, industrial-scale production of coated microneedle patches, a continuous coating method which utilises conventional pharmaceutical processes is an attractive prospect. Here, the potential of spray-coating silicon microneedle patches using a conventional film-coating process was evaluated and the key process parameters which impact on coating coalescence and weight were identified by employing a fractional factorial design to coat flat silicon patches. Processing parameters analysed included concentration of coating material, liquid input rate, duration of spraying, atomisation air pressure, gun-to-surface distance and air cap setting. Two film-coating materials were investigated ; hydroxypropylmethylcellulose (HPMC) and carboxymethylcellulose (CMC). HPMC readily formed a film-coat on silicon when suitable spray coating parameter settings were determined. CMC films required the inclusion of a surfactant (1%, w/w Tween 80) to facilitate coalescence of the sprayed droplets on the silicon surface. Spray coating parameters identified by experimental design, successfully coated 280 μm silicon microneedle arrays, producing an intact film-coat, which follows the contours of the microneedle array without occlusion of the microneedle shape. This study demonstrates a novel method of coating microneedle arrays with biocompatible polymers using a conventional film-coating process. It is the first study to indicate the thickness and roughness of coatings applied to microneedle arrays. The study also highlights the importance of identifying suitable processing parameters when film coating substrates of micron dimensions. The ability of a fractional factorial design to identify these critical parameters is also demonstrated. The polymer coatings applied in this study can potentially be drug loaded for intradermal drug and vaccine delivery.

microneedle; spray coat; silicon; hydroxypropylmethylcellulose; carboxymethylcellulose

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Podaci o izdanju

415 (1/2)

2011.

140-149

objavljeno

0378-5173

10.1016/j.ijpharm.2011.05.064

Povezanost rada

Farmacija, Biotehnologija, Biologija

Poveznice
Indeksiranost