engleski

Oral bullous eruption after taking lisinopril—case report and literature review

Drug-induced lesions of oral mucosa are well-established side effect of different commonly used drugs. A female patient under treatment for hypertension with an angiotensin-converting enzyme inhibitor(ACE inhibitor), lisinopril developed blisters and ulcerations on oral mucosa 3 weeks after lisinopril intake. Due to clinical finding drug-induced pemhigus was considered.However, direct and indirect immunofluorescence analysis revealed no autoantibodies that are commonlypresent in pemhigus, while histological study suggested allergic reaction. Lisinopril was discontinued from further therapy and after a month after her first arrival patient has experienced complete remission of the disease. This case raises the question, whether the term pemphigus in druginduced reactions could be used when immunopathological criteria for pemphigus are not fulfilled.

lisinopril ; blisters ; ulcerations ; oral mucosa

nije evidentirano