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High-performance liquid chromatography – an effective tool for quality control of natural cholesterol-lowering agents (CROSBI ID 50370)

Prilog u knjizi | izvorni znanstveni rad

Mornar, Ana ; Sertić, Miranda ; Nigović, Biljana High-performance liquid chromatography – an effective tool for quality control of natural cholesterol-lowering agents // High-performance liquid chromatography (HPLC) : principles, practices and procedures / Yuegang, Zuo (ur.). New York (NY): Nova Science Publishers, 2014. str. 87-128

Podaci o odgovornosti

Mornar, Ana ; Sertić, Miranda ; Nigović, Biljana

engleski

High-performance liquid chromatography – an effective tool for quality control of natural cholesterol-lowering agents

Hyperlipidemia is a heterogeneous group of disorders characterized by an excess of lipids in the bloodstream. Regardless of the cause, it is a major modifiable risk factor for artherosclerosis or coronary artery disease. The most commonly used medication for the treatment of high cholesterol levels are statins such as atorvastatin, simvastatin and lovastatin. Although safe and effective, statins can cause muscle problems, lung and liver disorders as well as kidney damage. Therefore, many patients seek alternative therapies to control their cholesterol levels. Many natural cholesterol-lowering agents are widely available to the public as dietary supplements. A dietary supplement, also known as a food supplement, is a preparation intended to supplement the diet and provide nutrients. Dietary supplements are usually used by patients at their own discretion, in an unmonitored setting and without the input of their physicians. Dietary supplements are readily available, not classified as over-the-counter medications, and not regulated as such. Health practitioners and patients often consider these products safe and probably effective. Unfortunately, information on dietary supplements in nonmedical literature and even in scientific literature is usually unreliable. Moreover, numerous studies have used products that were not well characterized. There is no uniform legislation in the dietary supplements area despite their ever growing popularity and presence on the market. Health safety, nutritional value and laboratory control of declared content is very rare. Therefore, greater attention has recently been given to quality control of dietary supplements. Today advance analytical techniques can be employed for identification and quantification of active compounds as well as toxic ingredients in dietary supplements. Due to its superior precision, high resolution and capacity to analyze thermally labile and non-volatile compounds, high performance liquid chromatography is applied for the quality control of dietary supplements. In this chapter a critical review on chromatographic methods for quality control of most frequently used natural cholesterol-lowering dietary supplements such as red fermented rice, artichoke, phytosterols, omega-3 fatty acids, green tea, soybean, gugulipid, coenzyme Q10, taurine, flax seeds and policosanol is given. Special attention is paid to determination of active ingredients as well as toxic compounds. Additionally, sample preparation procedures and chromatographic methods used for determination of active ingredients in biological fluids are discussed.

high performance liquid chromatography, hyperlipidemia, natural cholesterol-lowering agents

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Podaci o prilogu

87-128.

objavljeno

Podaci o knjizi

High-performance liquid chromatography (HPLC) : principles, practices and procedures

Yuegang, Zuo

New York (NY): Nova Science Publishers

2014.

978-1-62948-854-7

Povezanost rada

Farmacija