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Polymeric Micelles in Ocular Drug Delivery : Rationale, Strategies and Challenges (CROSBI ID 202091)

Prilog u časopisu | pregledni rad (znanstveni) | međunarodna recenzija

Pepić, Ivan ; Lovrić, Jasmina ; Filipović-Grčić, Jelena Polymeric Micelles in Ocular Drug Delivery : Rationale, Strategies and Challenges // Chemical and biochemical engineering quarterly, 26 (2012), 4; 365-377

Podaci o odgovornosti

Pepić, Ivan ; Lovrić, Jasmina ; Filipović-Grčić, Jelena

engleski

Polymeric Micelles in Ocular Drug Delivery : Rationale, Strategies and Challenges

Polymeric micelles that can deliver drug to intended sites of the eye have attracted much scientific attention recently. The aim here is to review the aqueous-based formulation of drug loaded polymeric micelles that hold significant promise for ophthalmic drug delivery. These innovative nanosystems can provide the biopharmaceutical advantages of higher permeation and enhancement of residence time at ocular surface for better drug absorption through ocular barriers. Mucoadhesive properties of biopolymers forming micelle enhance their contact time and minimize their elimination from the absorbing surface, consequently increasing the bioavailability of the drug. Their physicochemical characteristics are also important with respect to the industrial production and patient compliance. Drug loaded polymeric micelles can be fabricated by simple and cost effective techniques with improved physical stability which fulfils the requirements for industrial acceptance. Innovative polymeric micelle formulations allow their easy application in the form of eye drops without blurring of vision and discomfort, thus achieving patient compliance requirements.

polymeric micelles; ocular barriers; ocular delivery; ocular bioavailability; size; surface charge; in vitro stability; eye biofate; ocular permeability; safety

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Podaci o izdanju

26 (4)

2012.

365-377

objavljeno

0352-9568

Povezanost rada

Farmacija

Poveznice
Indeksiranost