engleski

Telomere length shortening is associated with disease evolution in chronic myelogenous leukemia

Teleomere length were studied in a group or patients with Chronic myelogenous leukemia by Southern blot hybridization using the TTAGGGx4 probe. Forty one patients in the chronic phase of CML were studied; 32/412 (78%) showed telomere reduction (< 7.6Kb) relative to age-matched controls and the mean peak TRA was 6.4 kB. Serial samples were analyzed from 12 patients both at chronic phase and during the blast crisis. The leukocyte DNA from all 12 patients in acclerated phase and /or blast crisis showed telomere reduction relative to age mathched controls and the mean peak TRA was 4.1. These data show that a marked reduction in telomere length is associated wiht disease progression in CML.

telomere; leukemia; progression

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