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Computational approach to utilisation of mitochondrial DNA in the verification of complex pedigree errors (CROSBI ID 209685)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Čačić, Mato ; Čubrić-Čurik, Vlatka ; Ristov, Strahil ; Čurik, Ino Computational approach to utilisation of mitochondrial DNA in the verification of complex pedigree errors // Livestock science, 169 (2014), 42-47. doi: 10.1016/j.livsci.2014.09.009

Podaci o odgovornosti

Čačić, Mato ; Čubrić-Čurik, Vlatka ; Ristov, Strahil ; Čurik, Ino

engleski

Computational approach to utilisation of mitochondrial DNA in the verification of complex pedigree errors

Mitochondrial DNA information can be used to verify pedigree concordance of both close and remote relatives along maternal lines. Different haplotypes in the same maternal line point out to an error in the pedigree. This has been used in several studies as the indication of the accuracy of the pedigree data. In all of these studies the collation of the haplotype data has been performed manually. With large pedigrees this is a tedious work prone to mistakes. We present the computational approach to this task based on the algorithm that systematically traces non- concordance among all sequenced individuals through maternal pedigree. Based on the number of found errors, we have introduced several numerical descriptors of pedigree quality. We demonstrate the functionality of our program with the analysis of a small example taken from a long and complex Lipizzan horse pedigree.

Pedigree errors; Mitochondrial DNA; Maternal lineage; Complex pedigree; Lipizzan horse

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Podaci o izdanju

169

2014.

42-47

objavljeno

1871-1413

10.1016/j.livsci.2014.09.009

Povezanost rada

Računarstvo, Poljoprivreda (agronomija)

Poveznice
Indeksiranost