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Do physicians follow suggested algorithm for thrombophilia testing: our experience for APCR and FVL (CROSBI ID 619380)

Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija

Ćelap, Ivana ; Štefanović, Mario Do physicians follow suggested algorithm for thrombophilia testing: our experience for APCR and FVL // Clinical chemistry and laboratory medicine / Plebani, Mario (ur.). 2011. str. S496-S496

Podaci o odgovornosti

Ćelap, Ivana ; Štefanović, Mario

engleski

Do physicians follow suggested algorithm for thrombophilia testing: our experience for APCR and FVL

Two discoveries made a major advance in the laboratory assessment of thrombotic risk, an inherited form of resistance to the activated protein C (APCR) and a missense mutation in the factor V gene (FVL). Many factors, such as age, gender, pregnancy and estrogen use influence sensitivity to APC. Familiar APC resistance is predominatly caused by factor V Leiden. New, modified coagulation assays for APC resistance are highly sensitive and specific for FVL, and thus laboratory diagnostic algorithm for thrombophilia screening prefers APCR funtional test to be done before FVL DNA-based test. Functional APCR test is quicker, easier and more cost-effective than FVL genotyping. Countinuos increase of FVL genotype requests in our laboratory last few years suggest that physicians do not follow suggested algorithm for thrombophilia screening. Data were collected from Laboratory Information System for the period from January 2007 till December 2010. 534 FVL genotype and 22 APCR requests were recieved. Among APCR requests 7 patients had increased APCR ; 2 was confirmed as heterozygots for FVL and 1 was not genotyped. One patient had normal APCR and genotyping was not performed. 512 FVL genotypes were done without prior APCR test. Although there are a few reasonable conditions (eg. oral anticoagulant therapy) in which FVL genotyping is suggested rather than APCR functional assay, our observation has shown that further efforts in education of physicians should be done

thrombophilia testing; APCR; FV Leiden

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Podaci o prilogu

S496-S496.

2011.

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objavljeno

Podaci o matičnoj publikaciji

Clinical chemistry and laboratory medicine

Plebani, Mario

Berlin: Walter de Gruyter

1434-6621

Podaci o skupu

21st International Congress of Clinical Chemistry and Laboratory Medicine and 19th IFCC-EFCC European Congress of Clinical Chemistry and Laboratory Medicine

poster

15.05.2011-19.05.2011

Berlin, Njemačka

Povezanost rada

Farmacija

Indeksiranost