Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

In vitro genotoxicity of mycotoxins ochratoxin A and fumonisin B1 could be prevented by sodium copper chlorophyllin – Implication to their genotoxic mechanism (CROSBI ID 215548)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Domijan, Ana-Marija ; Gajski, Goran ; Novak Jovanović, Ivana ; Gerić, Marko ; Garaj-Vrhovac, Vera In vitro genotoxicity of mycotoxins ochratoxin A and fumonisin B1 could be prevented by sodium copper chlorophyllin – Implication to their genotoxic mechanism // Food chemistry, 170 (2015), 455-462. doi: 10.1016/j.foodchem.2014.08.036

Podaci o odgovornosti

Domijan, Ana-Marija ; Gajski, Goran ; Novak Jovanović, Ivana ; Gerić, Marko ; Garaj-Vrhovac, Vera

engleski

In vitro genotoxicity of mycotoxins ochratoxin A and fumonisin B1 could be prevented by sodium copper chlorophyllin – Implication to their genotoxic mechanism

The aim of this study was to investigate the possible protective effect of sodium copper chlorophyllin (CHL) against cytotoxicity and DNA damage induced by mycotoxins ochratoxin A (OTA) and fumonisin B1 (FB1). CHL (0.1–100 μg/ml) alone had no impact on cell viability and genome damage in the primary human peripheral blood lymphocytes (HPBLs) and exhibited free radical scavenging activity in the DPPH assay. Both mycotoxins, OTA (4 μmol/l) and FB1 (20 μg/ml), induced DNA damage in HPBLs already after 1 h exposure. When the HPBLs were co-exposed to CHL (10 and 100 μg/ml) and OTA (4 μmol/l) or FB1 (20 μg/ml) for 1 h, CHL protected against cell and DNA damage induced by both mycotoxins, implying that OTA and FB1 cytogenotoxicity mechanisms function at least partially through oxidative stress. Therefore, CHL could be a perfect candidate for possible use as an antioxidant.

Chlorophyllin; Mycotoxins; Human lymphocytes; DNA damage; Oxidative stress; Protective effect

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

170

2015.

455-462

objavljeno

0308-8146

10.1016/j.foodchem.2014.08.036

Povezanost rada

Farmacija, Prehrambena tehnologija, Biologija

Poveznice
Indeksiranost