Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

The role of sevoflurane and ionising radiation on the level of primary DNA damage measured in blood and different organs of Swiss albino mice by the alkaline comet assay (CROSBI ID 623277)

Prilog sa skupa u zborniku | izvorni znanstveni rad | domaća recenzija

Benković, Vesna ; Milić, Mirta ; Horvat Knežević, Anica ; Halovanović, Sanja ; Borojević, Nikola ; Oršolić, Nada The role of sevoflurane and ionising radiation on the level of primary DNA damage measured in blood and different organs of Swiss albino mice by the alkaline comet assay // Proceedings of the tenth Symposium of the Croatian Radiation Protection Association / Petrinec, Branko ; Bituh, Tomislav ; Milić, Mirta et al. (ur.). Zagreb: Denona, 2015. str. 126-131

Podaci o odgovornosti

Benković, Vesna ; Milić, Mirta ; Horvat Knežević, Anica ; Halovanović, Sanja ; Borojević, Nikola ; Oršolić, Nada

engleski

The role of sevoflurane and ionising radiation on the level of primary DNA damage measured in blood and different organs of Swiss albino mice by the alkaline comet assay

Sevoflurane is general anaesthetic suitable for short surgical procedures due to its quick induction of anaesthesia, maintaining spontaneous breathing frequency and hemodynamic stability of patients. However, it can directly trigger the formation of peroxynitrite, significantly increase intracellular levels of H2O2, peroxide, superoxide anion and nitric oxide in peripheral polymorphonuclear neutrophils 1h after the treatment ; lowering the levels of intracellular glutathione, and increase radiosensitivity of cells also exposed to ionising radiation (IR). We wanted to evaluate the level of sinergistic effect and possible radiosensitivity DNA damage in blood, and different organs of Swiss albino mice after exposure to both sevoflurane (2.4 %, 50:50) and the 1Gy gamma-ray radiation generally used in diagnostic purposes after 0, 2, 6 and 24 hours from the combined treatment with alkaline comet assay. Combined exposure to sevoflurane and IR has demonstrated synergistic effect. Due to metabolising of the sevoflurane, there was different sensitivity between blood, liver, kidney and brain cells.

sevoflurane ; ionising radiation ; Swiss albino mice ; comet assay

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o prilogu

126-131.

2015.

objavljeno

Podaci o matičnoj publikaciji

Proceedings of the tenth Symposium of the Croatian Radiation Protection Association

Petrinec, Branko ; Bituh, Tomislav ; Milić, Mirta ; Kopjar, Nevenka

Zagreb: Denona

1849-5060

Podaci o skupu

10th Symposium of the Croatian Radiation Protection Association with international participation

poster

15.04.2015-17.04.2015

Šibenik, Hrvatska

Povezanost rada

Javno zdravstvo i zdravstvena zaštita, Farmacija, Biologija