Estimation of chromatographic lipophilicity of some D-homo androstene derivatives (CROSBI ID 222626)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Perišić Janjić, Nada ; Penov Gaši, Katarina ; Djurendić, Evgenija ; Savić, Marina ; Kovačević, Strahinja ; Jokić, Stela ; Podunavac-Kuzmanović, Sanja
engleski
Estimation of chromatographic lipophilicity of some D-homo androstene derivatives
Quantitative structure-retention relationship (QSRR) method was applied to study the chromatographic behaviour of D-homo-androstene derivatives 1-7. Retention constants (RM 0) of the analysed derivatives were determined by reversed-phase high-performance thin-layer chromatography (RP HPTLC) on C18 plates by using four mobile phase mixtures: methanol-water, acetone-water, acetonitrile-water, and dioxane-water. Correlation analysis based on multiple regression method was applied in order to model chromatographic retention by means of nine different lipophilicity descriptors (logP). The developed QSRR models were cross-validated and high-quality validation parameters were obtained by leave-one-out method. It was found that the derived QSRR models have a good predictive ability.
QSRR ; chemometrics ; RP HPTLC ; lipophilicity
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Podaci o izdanju
Povezanost rada
Biotehnologija, Kemija, Kemijsko inženjerstvo