Study of kinetic parameters and possible inhibitory effect on the tyrosinase of the halogenated boroxine dipotassium trioxohydroxytetrafluorotriborate K2[B303F4OH] (CROSBI ID 633779)
Prilog sa skupa u zborniku | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Marasović, Maja ; Čorić, Zrinka ; Miloš, Mladen ; Galić, Borivoj
engleski
Study of kinetic parameters and possible inhibitory effect on the tyrosinase of the halogenated boroxine dipotassium trioxohydroxytetrafluorotriborate K2[B303F4OH]
Abstract: A number of biochemical and medical researches detected increased activity of tyrosinase in the skin tumor cells.The most famous and available inhibitor kojic acid has a lot of side effects and is not completely safe for use. Objectives: In this paper is described the study of inhibitory influence of halogen boroxine K2[B303F4OH] on tyrosinase. It was encouraged by the ability of compound mentioned above to inhibit enzymes by metal ion chelation and its easy synthesis and formulation to cosmetic products applicable to the skin without serious side effects. Method: Tyrosinase activity was measured by spectrophotometric analysis of the appearance of dopachrome pigment at a wavelength of 475 nm.Tyrosinase exhibits typical Michaelis-Menten kinetics. Results: Tests of the proposed inhibition of the enzyme tyrosinase showed that K2[B3O3F4OH] has weak inhibitory properties. Conclusion: It will be neccesser to search for new ways of antitumor mechanism different from according previous results obvious one.
Tyrosinase inhibitors ; kojik acid ; boronic acids ; halogenated boroxine dipotassium trioxohydroxytetrafluorotriborate
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Podaci o prilogu
679-804.
2016.
objavljeno
Podaci o matičnoj publikaciji
Proc. of the CBU International Conference on Inovations in Science and Education 2016.
Hajek, P ; Sahota, T ; Jones, MA
Prag: Central Bohemia Univ, P Prague, Czech Republic
1805-9961
Podaci o skupu
CBU International Conference on Inovations in Science and Education 2016.
ostalo
23.03.2016-25.03.2016
Prag, Češka Republika