engleski

Kinetics and degradation pathways of photolytic and photocatalytic oxidation of the anthelmintic drug praziquantel

In this study, an anthelmintic drug, praziquantel(PZQ), was degraded using the direct photolysis, photocatalysis, and oxidation processes including UV radiation, TiO2 film, and hydrogen peroxide. The photolytic degradation with predominant wavelengths of 185/254 nm (UV-C) proved to be more efficient with a half-life of 3.13 min compared to the radiation of 365 nm (UV-A) where the degradation did not occur. In order to enhance the rate of PZQ photolytic degradation, H2O2 was added, which resulted in two to three times higher degradation rates. In the photocatalytic degradation, TiO2 film was used as catalyst. The degradation was ten times faster in the photocatalytic experiments where UV-C light (k=0.2390 min-1) was used than in those with UV-A (k=0.0201 min-1). Comparing the results from all performed experiments it can be concluded that the UV-C/TiO2/H2O2 process yielded the highest degradation rate and complete degradation of PZQ was obtained in less than 7 minutes. The degradation of PZQ followed the first order kinetics in all the experiments. The photo degradation was inhibited in the presence of methanol. The degradation pathways and the structural formulae of five degradation products (m/z 273, 269, 189, 147, 132) were proposed based on the liquid chromatography tandem mass spectrometry analysis.

pharmaceuticals ; praziquantel ; photolysis and photocatalysis ; titanium dioxide film ; photodegradation pathway

Special Issue on Emerging Contaminants in engineered and natural environment.