UV photolysis of diclofenac in water; kinetics, degradation pathway and environmental aspects (CROSBI ID 228769)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Kovačić, Marin ; Juretić Perišić, Daria ; Biošić, Martina ; Kušić, Hrvoje ; Babić, Sandra ; Lončarić Božić, Ana
engleski
UV photolysis of diclofenac in water; kinetics, degradation pathway and environmental aspects
In this study, the photolysis behavior of commonly used anti-inflammatory drug diclofenac (DCF) was investigated using UV-C and UV-A irradiation. In that purpose, DCF conversion kinetics, mineralization of organic content, biodegradability, and toxicity were monitored and compared. The results showed different kinetics of DCF conversion regarding the type of UV source applied. However, in both cases, the mineralization extent reached upon complete DCF conversion is rather low (≤10 %), suggesting that the majority of DCF was transformed into by-products. Formation/degradation of main degradation by- products was monitored using high performance liquid chromatography–electrospray ionization tandem mass spectrometry (HPLC–ESI-MS/MS), whereas different profiles were obtained by UV- C and UV-A photolysis. The results of bioassays revealed that biodegradability of DCF solutions remained low through the applied treatments. The toxicity of irradiated DCF solutions was evaluated using Vibrio fischeri. A significant reduction of toxicity, especially in the case of UV-A radiation, was observed upon complete degradation of DCF. In addition to toxicity reduction, calculated Log KOW values of DCF degradation by-products indicate their low potential for bioaccumulation (Log KOW≤ 3) in comparison to the parent substance.
diclofenac ; UV photolysis ; degradation pathway ; biodegradability ; toxicity
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
23 (15)
2016.
14908-14917
objavljeno
0944-1344
1614-7499
10.1007/s11356-016-6580-x
Povezanost rada
Interdisciplinarne tehničke znanosti, Kemija, Kemijsko inženjerstvo