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izvor podataka: crosbi

Appropriate time of thrombophilia testing related to oral anticoagulant therapy: are recommended guidelines followed (CROSBI ID 636077)

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Margetić Sandra ; Getaldić Biserka ; Ćelap Ivana ; Vrkić Nada Appropriate time of thrombophilia testing related to oral anticoagulant therapy: are recommended guidelines followed // Biochemia medica / Šimundić Ana-Maria (ur.). 2013. str. A35-A35

Podaci o odgovornosti

Margetić Sandra ; Getaldić Biserka ; Ćelap Ivana ; Vrkić Nada

engleski

Appropriate time of thrombophilia testing related to oral anticoagulant therapy: are recommended guidelines followed

Background: The appropriate time of testing related to oral anticoagulant therapy (OAT) is one of the crucial preanalytical variables for thrombophilia investigation since many of these tests are affected by this therapy. In order to gain insight into physicians ordering practices, we performed a retrospective analysis of consecutive thrombophilia tests ordered during the 10-month period. Materials and methods: The study included lupus anticoagulant (LA) investigation and functional assays for protein C (PC), protein (PS) and resistance to activated protein C (APCR), using commercially available coagulation methods (Siemens, Germany). Results: A total number of tests performed was as follows: 853 (LA), 608 (PC), 443 (PS) and 540 (APCR.) Proportions of positive results for each test were: LA = 35/853 (4.1%), PC = 28/608 (4.6%), PS = 50/443 (11.3%) and APCR = 52/540 (9.6%). Of all positive test results, 10/35 (28.6%) for LA, 20/28 (71.4%) for PC, 22/50 (44%) for PS and 3/52 (5.8%) for APCR were attributable to OAT, thus representing false- positive results that could have considerable implications for patients. Conclusions: Our findings suggest the appropriate time of testing related to OAT to be simply overlooked by clinicians managing patients with thrombosis, thus resulting with a huge waste of resources with concomitant high likelihood of false-positive test results. Our findings indicate that thrombophilia testing in patients on OAT still occurs frequently in clinical practice despite recommended guidelines. The net effect of such testing is likely to be more detrimental than beneficial for the patient. On the basis of our results, it is obvious that laboratories need to take a more substantial role in the thrombophilia investigation process than just providing doctors with numbers. The corrective actions should include ongoing education of clinicians and reject testing in patients on OAT since it would be more rational, cost-effective and beneficial for patients.

thrombophilia testing; oral anticoagulant therapy; preanalytical variable

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Podaci o prilogu

A35-A35.

2013.

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objavljeno

Podaci o matičnoj publikaciji

Biochemia medica

Šimundić Ana-Maria

Zagreb: Hrvatsko društvo za medicinsku biokemiju i laboratorijsku medicinu/Medicinska naklada

1330-0962

Podaci o skupu

2nd EFLM-BD European Conference on Preanalytical Phase: Preanalytical quality improvement – in quality we trust

poster

01.03.2013-02.03.2013

Zagreb, Hrvatska

Povezanost rada

Kliničke medicinske znanosti, Farmacija

Indeksiranost