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izvor podataka: crosbi

Serum activities of adenosine deaminase, dipeptidyl peptidase IV and prolyl endopeptidase in patients with fibromyalgia: diagnostic implications (CROSBI ID 231829)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Čulić, Ognjen ; Cordero, Mario D. ; Žanić- Grubišić, Tihana ; Somborac-Bačura, Anita ; Batičić Pučar, Lara ; Detel, Dijana ; Varljen, Jadranka ; Barišić, Karmela Serum activities of adenosine deaminase, dipeptidyl peptidase IV and prolyl endopeptidase in patients with fibromyalgia: diagnostic implications // Clinical rheumatology, 35 (2016), 10; 2565-2571. doi: 10.1007/s10067-016-3377-8

Podaci o odgovornosti

Čulić, Ognjen ; Cordero, Mario D. ; Žanić- Grubišić, Tihana ; Somborac-Bačura, Anita ; Batičić Pučar, Lara ; Detel, Dijana ; Varljen, Jadranka ; Barišić, Karmela

engleski

Serum activities of adenosine deaminase, dipeptidyl peptidase IV and prolyl endopeptidase in patients with fibromyalgia: diagnostic implications

Fibromyalgia (FM) is a chronic pain syndrome with number of symptoms that present challenge in terms of diagnosis and treatment. Patients with FM show abnormal profile of purines in plasma. In this work, we measured serum activities of enzymes involved in purine metabolism, namely total adenosine deaminase (ADE) and its isoforms (ADE1 and ADE2), ecto- ATPase, and 5′- nucleotidase (5′-NT). We also measured activity of dipeptidyl peptidase IV (DPPIV) and prolyl endopeptidase (PEP). Spectrophotometric and fluorometric methods were used for enzyme activity determinations. Enzyme activities were measured in sera of 24 patients with FM that were not undergoing pharmacological treatment during the study. Control group comprised 32 healthy control subjects. Significantly higher activities of total ADE (P = 0.025) and ADE2 (P = 0.011) were observed in FM patients, while no significant differences in ADE1, ecto-ATPase, and 5′-NT activities (P > 0.05) were found when compared to healthy controls. Moreover, increase in the activity of DPPIV (P = 0.015) and lower activity of PEP (P = 0.011) were also found in the FM group. ROC analysis pointed to different diagnostic sensitivities/specificities for individual enzyme activities measured as follows: ADE (50.0/87.5), ADE2 (41.7/90.6), DPPIV (62.5/71.9), and PEP (83.3/62.5). ADE2 and PEP were shown to be independent predictors of FM, while combination of the two gives AUC of 0.786 (95 % confidence interval of 0.656–0.885, P < 0.05). Our results are showing that serum activities of ADE2 and PEP could be useful as biomarkers for FM diagnosis. However, relatively low diagnostic sensitivity of ADE2 and specificity of PEP must be taken into account.

Adenosine ; Diagnostic biomarker ; Fibromyalgia ; Serum enzymes

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Podaci o izdanju

35 (10)

2016.

2565-2571

objavljeno

0770-3198

10.1007/s10067-016-3377-8

Povezanost rada

Farmacija, Temeljne medicinske znanosti

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