engleski

FOOD AND DRUG INTERACTIONS

Introduction: It is well-known that drug-drug interaction may occur when two or more drugs are administered together. However, this applies also to food, dietary supplements, or beverages in a situation when they are taken at the same time with drugs. A food and drug interaction can prevent a medicine from working the way it should, cause a side effect from a medicine to get worse or better, and cause a new side effect. The aim of the study was to identify the most frequent food and drug interactions. Methods: The electronic database PubMed was searched for relevant studies (2001 till February 2016). Additional references were obtained from reviewed articles. Results: A total of 40 articles were included in the review. Grapefruit (food and juice), orange juice, green leafy vegetables, xanthines- containing beverages (e.g. coffee, tea), tyramine-containing food (e.g. chocolate, aged and matured cheeses, red wine, draft beers), milk, and St. Johns worth are considered as the most common food, dietary supplement, or beverages that interact with drugs. Warfarin, statins, calcium channel blockers, antibiotics, and monoamine oxidase inhibitors are drugs that frequently interfere with food. Food and drug interactions may result in changes in bioavailability of the drug. Food may also alter the activity of a drug-metabolizing enzyme resulting in either decreased or increased concentration of drug. Cytochrome P 450 3A4 is the most common enzyme included in this type of interaction. Conclusion: In the real world the efficacy of prescribed medication may be altered by the patient dietary behaviour. There is a need to write guidelines for patients regarding food and drug interactions.

food ; drug ; interactions

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