engleski

Chemical cleaning of adsorbed pharmaceutical on NF/RO membranes

Nanofiltration (NF) and reverse osmosis (RO) have proved to be effective in the removal of various pharmaceuticals. One of the main rejection mechanisms is interaction/adsorption since pharmaceuticals, especially hydrophobic, adsorb on membrane polymeric matrix. Albendazole as hydrophobic pharmaceutical passed through 6 different NF/RO membranes (NF, NF90, NF270, BW30, UTC-70HA and XLE) at a pressure of 10 bar. Adsorption was confirmed with increase in concentrations of albendazole in permeate, and therefore decrease in rejection factor, and appearance of new peaks (showing new bonds) on Fourier transformation infrared (FTIR) spectra. Commercially available cleaning solution (Nalco PC99) was used to remove adsorbed albendazole from the membranes. FTIR spectra were used to confirm efficacy of cleaning agent. The results showed that commercially available cleaning solution was not appropriate for removal of adsorbed hydrophobic compound. FTIR spectra after adsorption and after chemical cleaning were similar showing that bonds (direct H-bonding between H of the OH group and N of the heterocyclic ring, stretching of C=C double bond in aromatic ring, string bending of the methyl group) between membrane polymeric matrix and albendazole were still present.

adsorption, pharmaceutical, cleaning, nanofiltration, reverse osmosis

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