Prediction of particle size distribution of dronedarone hydrochloride in spiral jet mill using design of experiments (CROSBI ID 245826)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Kordić, Šimo ; Matijašić, Gordana ; Gretić, Matija
engleski
Prediction of particle size distribution of dronedarone hydrochloride in spiral jet mill using design of experiments
In pharmaceutical industry, micronization is used to achieve solubility enhancement through the increase in specific surface area, and finally improving the dissolution rate of the drug. Industrial application of micronization is mostly based on experience and trial and error method. This research deals with the micronization of dronedarone hydrochloride and the path for evaluation of characteristics of micronized drug. Micronization was performed in laboratory spiral jet mill and the samples were analyzed to determine particle size distribution, span of distribution, sphericity, shape, and specific surface area. Results were analyzed using analysis of variance and in terms of specific energy consumption. Paths for evaluation of particle size and span of distribution were proposed and good correlation between experimental and model results was achieved.
design of experiments ; dronedarone hydrochloride ; energy consumption ; kinetic energy ; micronization ; spiral jet mill
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Podaci o izdanju
205 (2)
2018.
197-206
objavljeno
0098-6445
1563-5201
10.1080/00986445.2017.1380632