engleski

Structural 5-day weight loss program ; results of 3 months follow-up

Data from 58 obese patients (13 men, 45 women), mean age 45 years (20-68), attending structural weight loss program at the Division of Endocrinology, University Hospital Centre Zagreb, were analysed. A 5-day program included daily consultations with a multidisciplinary healthcare team. The team led by an endocrinologist-diabetologist and nurse- educator, also included a nutritionist, physiotherapist, psychiatrist, psychologist who provided psychological support and facilitated behaviour modifications and other subspecialists. At the baseline and after 3 months we estimated anthropometric values (height, weight, BMI) as well as body composition measured by bioelectrical impedance analysis (fat mass, muscle mass). Baseline mean body mass was 125 kg (78-238), BMI was 44.2 kg/m2 (30-66), fat mass 59.4 kg (25.1-120.4), muscle mass 61.4 kg (43.8-117) ; after 3 months mean body mass was 119 kg (72.8-197.3), BMI 42.1 kg/m2 (27.9-64.4), fat mass 53.6 kg (23.6- 103.7), muscle mass 62.3 kg (43.7-107.7). Statistical analyses showed significant decrease in body weight, BMI and body fat mass after 3 months (p=0.000), but no significant difference in muscle mass (p=0.969). Patients were divided into two groups ; those who did not lose any weight (≤1 kg) were considered non- responders, others were considered responders. Thirteen patients (22%) were non- responders, and 45 patients (78%) were responders. Mean weight loss of responders was 6.2% (1-38). According to FDA Guidance for developing products for weight management the product is effective if there is a statistically significant decrease in body weight of ≥5% beyond the placebo effect or at least 35% of patients lose ≥5% of their body weight at 3 months. In conclusion, overall response to our structured program is effective during the 3 months follow-up period. It is fulfilling criteria for weight management products even without pharmacotherapy. The overall weight loss corresponds to fat mass, with preserved muscle mass.

Weight loss ; Structural program ; Obestiy

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